SANE was established in 1986 by Marjorie Wallace after a ground-breaking series of articles in the Times newspaper. SANE raises awareness of severe mental illness and carries out vital medical reserch into schizophrenia and depression at the SANE Research Centre in Oxford. SANE's unique helpline, SANELINE, now receives some 40,000 calls per year from members of the public concerned about mental illness. SANE's website contains a wealth of information about mental illnesses including depression and manic depression, schizophrenia, anxiety and phobia to name but a few.